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Cholic, ursodesoxycholic, chenodesoxycholic, desoxycholic and hyodesoxycholic acids were dissolved in the propylene glycol to make solution and then above solution of cholanic acids on bile secretion was investigated by injecting those solutions into small intestine of rabbits and albino rats. The cholates in bile juice from rabbits injected with cholic acid were remarkably increased and therefore it exhibited a typical choleretic action. In view of pharmacological point, desoxycholic acid is considered as superior hydrocholeretic agent, and ursodesoxycholic and chenodesoxycholic acids have similar effect in decreasing order. However, the effect of bile secretion by hyodesoxycholic acid was almost negligible as that by propylene glycol administered. The cholate content in the bile juice from albino rat was increased by cholic and desoxycholic acids in decreasing order: i. e., they exhibited choleretic action. In the case of ursodesoxycholic and chenodesoxycholic acids, the concentration of cholate was slightly increased in bile juice from the rat, so that these cholates showed a weak choleretic action. While total output of bilirubin was increased by chenodesoxycholic acid, the other cholanic acid showed no effect in the rabbit.
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